CJC-1295 is a GHRH (the 44-amino acid long version) with 15 aminos
removed, thus a total of 29 amino acids, and bound to DAC it is also
called Drug Affinity Complex, and CJC-1295 is often referred to as GHRH
with Drug Affinity Complex, this essentialy lengthens its life span.
This is how its life is lengthened.
The modification of growth hormone releasing factor with D-Ala, Gln,
Ala, and Leu substitutions at positions 2, 8, 15, and 2 create a much
more stable peptide with the substitution at position 2 to prevent
DPP-IV cleavage, position 8 to reduce asparagine rearrangement or amide
hydrolysis to aspartic acid, position 15 to enhance bioactivity, and
position 27 to prevent methionine oxidation. By utilising the Drug
Affinity Complex technology to GRF, the peptide selectively binds to
circulating albumin after subcutaneous administration, thus prolonging
its half-life.
As you may notice its basically semorelin with 15 aminos removed.
This was because semorelin degrades too rapidly to really make it a
viable cost efficient option.
So they bonded it with an attached 3-maleimidopropionic acid (MPA)
unit, which results in binding to albumin after exogenous injection into
blood plasma, and creates a far longer half life, this is the DAC, or
druf affinity complex i made referance to earlier.
Now it works by this action as its a GHRH, or growth hormone
releasing hormone, In the healthy human body, large amounts of growth
hormone are stored in the pituitary. The cells within the pituitary
release growth hormone in response to signalling by GHRH (Growth Hormone
Releasing Hormone) Then the peptide Ghrelin is (of which GHRPs – Growth
Hormone Releasing Peptides – are mimetics), inhibited from releasing
these stores by Somatostatin. GHRH and Ghrelin act on different
populations of somatotropes (GH releasing cells). GHRP and Ghrelin
increase the number of somatotropes releasing GH but not the amount
released by each cell.
GHRH affects both the number of secreting cells and – moreso – the
amount they are actualy able to secrete. GHRH and Ghrelin are released
in specific patterns that vary depending on what the person involved is
doing, or has been doing post-exercise. Now CJC-1295 DAC has been proven
to stimulate slow wave sleep, and this is the period of sleep when most
of your bodys repairing work takes place on muscles and tissues etc.
Now most people can and will make GH in their own pituitary gland,
but not everyone can release it in the amounts needed, so from a
medicinal point CJC-1295 DAC can be very beneficial.
Now for its benefits to reach full potential, somatostatin needs to
be inhibited because we have just seen it inhibits gh release, so by
using a compound known as an Acetylcholineesterase inhibitor, now
Acetylcholineesterase inhibits acetylcholine, and Acetylcholine inhibits
somatostatin, so we want Acetylcholine in abundance, so by using an
Acetylcholineesterase inhibitor, we allow acetylcholine to inhibit
somatostatin, so increasing the amount of gh released when using
CJC-1295DAC. Got it? Ok re read that last passage.
The best of these Acetylcholineesterase inhibitors and there are lots like..
Physostigmine
Neostigmine
Pyridostigmine
Ambenonium
Demarcarium
Rivastigmine
Phenanthrene derivatives
Galantamine
Piperidines
Donepezil, also known as E2020
Tacrine, also known as tetrahydroaminoacridine (THA’)
Edrophonium
Huperzine A
Ladostigil,
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